ADVANTAGES

We performed a two-stage genomewide association study to discover and replicate genetic loci associated with gestational duration and the risk of preterm birth. Women in the discovery data set were participants in the research program of 23andMe, a personal genomics and biotechnology company. All the women provided written informed consent and answered surveys online according to a human-subjects protocol approved by Ethical and Independent Review Services (). Unrelated women of European ancestry who self-reported the gestational duration of their first live singleton birth were included in the analysis. Women with a medical indication for their preterm delivery were excluded; those who did not specify a medical indication were included to optimize sample size. Preterm-birth status was determined on the basis of dichotomization of gestational duration (preterm,

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